Prognostic implications of serum tumor necrosis factor-α concentration and its change in patients with hepatocellular carcinoma after stereotactic body radiation therapy
Objective To explore the prognostic role of serum tumor necrosis factor-α(TNF-α)concentration and its change before and after treatment in hepatocellular carcinoma(HCC)patients receiving stereotactic body radiation therapy(SBRT).Methods The clinical data of 42 HCC patients who received SBRT at Zhongshan Hospital,Fudan University,from October 2016 to June 2021,were retrospec-tively analyzed.The tumors were confined to the liver in all patients.Serum TNF-α concentration was tested before and after SBRT.The patients were grouped based on the baseline serum TNF-α concentration using the upper quartile.Kaplan-Meier method was used to cal-culate the survival rate,and log-rank test was used for survival comparison.The independent factors affecting the prognosis of the patients were analyzed using Cox proportional hazards regression model.Results For patients with baseline TNF-α concentration>10.05 pg/mL and≤10.05 pg/mL,respectively,the 1-year overall survival(OS)rates were 77.8%and 100.0%,the 2-year OS rates were 22.2%and 82.6%,and there was a significant difference in OS between the two groups(P=0.001).The 1-,2-,and 3-year progression-free survival(PFS)rates were 72.1%,51.9%,and 38.9%for patients with TNF-α concentration increased from post-to pre-SBRT,and 26.2%,17.5%,and 0%for patients with TNF-α concentration decreased from post-to pre-SBRT.There was a significant difference in PFS between the two groups(P=0.039).The baseline serum TNF-α concentration was an independent prognostic factor for OS(HR=7.668,95%CI:1.316-44.688,P=0.024).The change of serum TNF-α concentration before and after SBRT was an independent prognostic factor for PFS(HR=0.432,95%CI:0.190-0.979,P=0.044).Conclusions The baseline serum TNF-α concentration and the change of TNF-α concen-tration before and after SBRT are related to the prognosis of HCC patients receiving SBRT.
hepatocellular carcinomastereotactic body radiation therapyinflammatory factortumor necrosis factor-αprognosis
万方数据
维普
