Ovarian cancer is one of the most prevalent malignancies of the female reproductive system,and its mortality rate ranks first among gynecological malignant tumors.Due to the lack of specific symptoms in the early stage of the disease and the high heterogeneity of tumors,early diagnosis,therapeutic efficacy monitoring,and prognosis prediction of ovarian cancer have become three major challenges in clinical practice.In recent years,an increasing number of studies have focused on exploring biomarkers for ovarian cancer,intending to advance the field of precision medicine.This article aims to provide a comprehensive review of ovarian cancer biomarkers about auxiliary diagnosis,treatment response prediction,and prognosis evaluation,with the hope of offering valuable insights for individualized clinical de-cision-making for ovarian cancer patients.