Efficacy of Bedaquiline Combined with Background Regimen in the Treatment of Drug-Resistant Pulmonary Tuberculosis
Objective:To explore the efficacy of bedaquiline combined with background regimen in the treatment of drug-resistant pulmonary tuberculosis.Methods:A total of 159 patients with drug-resistant pulmonary tuberculosis admitted to Guangzhou Chest Hospital Guangdong Province from January 2022 to January 2023 were retrospctively selected and randomly grouped according to randomized control principle.The control group(80 cases)received conventional background regimen,and the study group(79 cases)was treated with bedaquiline on its basis.After 6 months,the lesion absorption rate,sputum conversion rate,and cavity closure rate were evaluated in both groups.The changes in serum liver function indicators,electrocardiogram QTc interval,and incidence of adverse reactions before and after treatment were compared between the two groups.Results:Compared with the control group,the study group showed significant improvement in lesion absorption rate,sputum conversion rate,and cavity closure rate(P＜0.05).Both groups had increased levels of ALT and AST after treatment(P＜0.05),but there was no statistically significant difference in ALT and AST levels between the two groups(P＞0.05).Both groups showed an increase in QTcF value and a decrease in heart rate after treatment(P＜0.05).The study group had significantly higher QTcF value but lower heart rate than the control group(P＜0.05).There was no significant difference between the two groups in terms of elevated transaminase level,decreased white blood cell count,or incidence of gastrointestinal reactions(P＞0.05),but the incidence of prolonged QT interval was in the study group higher than in control group(P＜0.05).Conclusion:Bedaquiline combined with background regimen has good efficacy for treating drug-resistant pulmonary tuberculosis without causing liver dysfunction;However,it is associated with a higher incidence of prolonged QT interval.
Drug-resistant pulmonary tuberculosisBedaquilineBackground regimenEffectivenessLiver function
万方数据
维普
