Study on the Effects of Methylprednone Impact Therapy on Children with Anaphylactoid Purpura
Objective To analyze the effects of impact therapy(methylprednisolone sodium succinate)in children with anaphylactoid purpura on the basis of conventional treatment.Methods 60 children with anaphylactoid purpura admitted from January 2021 to April 2023 were divided into control group and observation group by random number table method,with 30 cases in each group.The control group was treated with conventional methods,and the observation group was combined with impact therapy(methylprednisolone sodium succinate)on the basis of the control group.The time of clinical symptom resolution,hospital stay,clinical efficacy,immunological indexes,changes of inflammatory response indexes,and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of observation group was higher than that of the control group(P＜0.05).In the observation group,the time of purpura resolution,hospital stay,joint pain relief time,edema disappearance time and gastrointestinal symptoms relief time were shorter than those of the control group(P＜0.05).The levels of CD4+,CD3+ and CD4+/CD8+ in peripheral blood of the two groups showed an increasing trend,and the levels of the observation group were higher(P＜0.05).The levels of serum immunoglobulin A(IgA),tumor necrosis factor-α(TNF-α),immunoglobulin M(IgM),interleukin-6(IL-6),immunoglobulin E(IgE),interleukin-10(IL-10),complement C3 and peripheral blood CD8+ in both groups were decreased,and the levels of observation group were lower(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The application of impact therapy(methylprednisolone sodium succinate)in children with anaphylactoid purpura can help improve their immune function,relieve clinical symptoms,reduce the level of inflammatory mediators,and then improve clinical treatment effectiveness without increasing adverse reactions.
Children with anaphylactoid purpuraMethylprednisolone sodium succinateImpact therapy
万方数据
维普
