Effect of prophylactic antibiotic therapy on bite site infection after cobra bite
Objective To study the effect of prophylactic antibiotic therapy on bite site infection after cobra bite.Methods Thirty-seven patients with cobra bite poisoning treated in our hospital from January 1,2020 to December 1,2022 were randomly divided into control group(n =17)and observation group(n =20).The control group was given routine treatment,including antivenom,dexa-methasone sodium phosphate,tetanus antitoxin,wound debridement and negative pressure closed drainage.The observation group was given prophylactic antibiotics based on routine treatment,that is,intravenous drip of levofloxacin and sodium chloride injection for pre-vention for 3 days.The peripheral blood leukocyte count,C-reactive protein,procalcitonin,wound bacterial positive rate,wound suppura-tive rate and fever were observed and compared between the two groups.Results Before treatment,there were no significant differ-ences in white blood cell count,C-reactive protein and procalcitonin levels between the two groups(P>0.05).After a week of treat-ment,the white blood cell count,C-reactive protein and procalcitonin in the control group were higher than those in the observation group,were statistically significant(all P<0.05).The bacterial positive rate,wound pyosis rate and fever rate in control group were higher than those in observation group,were statistically significant(all P<0.05).Conclusion Early prophylactic use of levofloxa-cin helps to reduce local infection in cobra bites.
NETL
NSTL
万方数据
维普
