HbA1c结合神经肌电图在糖尿病周围神经病变早期诊断中的应用价值
Application value of HbA1c combined with neural electromyography in the early diagnosis of diabetic peripheral neuropathy
饶丹1
作者信息
- 1. 黔西南州人民医院神经电生理科,贵州兴义 562400
- 折叠
摘要
目的 研究糖化血红蛋白(HbA1c)结合神经肌电图在糖尿病周围神经病变(DPN)早期诊断中的应用价值.方法 选择2022 年1 月至2023 年1 月我院收治的45 例糖尿病合并DPN患者作为DPN组,选择同期收治的68 例非DPN糖尿病患者作为NDPN组.比较两组患者的HbA1c及神经肌电图,分析HbA1c结合神经肌电图在DPN早期诊断中的价值.结果 DPN组患者的HbA1c水平显著高于NDPN组,差异具有统计学意义(P<0.001).DPN组正中神经、腓总神经和尺神经的运动传导速度(MCV)与正中神经、腓浅神经和尺神经的感觉传导速度(SCV)均明显低于NDPN组,差异均有统计学意义(均P<0.05).HbA1c诊断DPN的ROC曲线下面积(AUC)为 0.85,当HbA1c在 8.12%时,敏感度与特异度分别为 89%、68%.各神经传导速度诊断DPN的AUC均>0.75,但单一指标的敏感度或特异度较低.HbA1c联合各神经传导速度诊断DPN的敏感度和特异度分别为98%和94%(P<0.05).结论 HbA1c联合神经肌电图在DPN的早期诊断中有极高的准确性和可靠性.
Abstract
Objective To investigate the application value of glycated hemoglobin A1c(HbA1c)combined with neural electromyo-graphy in the early diagnosis of diabetic peripheral neuropathy(DPN).Methods 45 diabetic patients with DPN admitted to our hospital from January 2022 to January 2023 were selected as the DPN group,while 68 diabetic patients without DPN admitted during the same period were selected as the non diabetic peripheral neuropathy(NDPN)group.HbA1c and neuroelectromyography of two groups were compared,and the diagnostic value of HbA1c combined with neuroelectromyography in diagnosing DPN was analyzed.Results The level of HbA1c in DPN group was significantly higher than that in NDPN group,there was statistically significant difference(P<0.001).Motor conduction velocity(MCV)of median nerve,common peroneal nerve,ulnar nerve,and sensory nerve conduction velocity(SCV)of median nerve,superficial peroneal nerve,ulnar nerve in DPN group were lower than that in NDPN group,there were statisti-cally significant difference(all P<0.05).The area under curve(AUC)of HbA1c for DPN diagnosis was0.85,and achieved a sensi-tivity rate of 89%and specificity rate of 68%when using a threshold set at 8.12%.The AUC of all nerve conduction velocities for DPN diagnosis were>0.75,however their sensitivity or specificity alone was relatively low.The sensitivity and specificity of HbA1c com-bined with nerve conduction velocity in the diagnosis of DPN were 98%and 94%,respectively(P<0.05).Conclusion HbA1c combined with neural electromyography has high accuracy and reliability in the early diagnosis of DPN..
关键词
糖尿病周围神经病变/神经肌电图/糖化血红蛋白/诊断价值Key words
Diabetic peripheral neuropathy/Neural electromyography/Glycated hemoglobin A1 c/Diagnostic value引用本文复制引用
出版年
2024
NETL
NSTL
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