Effect of Based-on-Timing Theory of Invasive-Noninvasive Sequential Mechani-cal Ventilation Therapy Combined with High-Flow Oxygen Therapy in Treat-ment of Mild-to-Moderate Acute Respiratory Distress Syndrome(ARDS)
Effect of Based-on-Timing Theory of Invasive-Noninvasive Sequential Mechani-cal Ventilation Therapy Combined with High-Flow Oxygen Therapy in Treat-ment of Mild-to-Moderate Acute Respiratory Distress Syndrome(ARDS)
Objective To investigate the therapeutic effect of based-on-timing theory of invasive-noninvasive sequential mechanical ventilation therapy combined with high-flow oxygen therapy in the treatment of mild-to-moderate ARDS.Methods Eighty patients with mild-to-moderate ARDS admitted to our hospital from October 2022 to January 2024 were selected as the research subjects and di-vided into the control group and the observation group by random number table method.The control group received conventional me-chanical ventilation combined with high-flow oxygen therapy,while the observation group received based-on-timing theory of invasive-noninvasive sequential mechanical ventilation therapy combined with high-flow oxygen therapy.The blood gas analysis indicators,circu-latory indicators,treatment-related indicators,and incidence of ventilator-associated pneumonia(VAP)were observed in the two groups at 24 and 48 h after treatment.Results After treatment for 24 and 48 h,the respiratory rate(RR),carbon dioxide partial pressure(PaCO2),oxygenation index(PaO2/FiO2),heart rate(HR),and mean arterial pressure(MAP)of the two groups were comparable,with no statistically significant differences(all P＞0.05).The total invasive mechanical ventilation time,total mechanical ventilation time,and ICU stay of the observation group were all significantly shorter than those of the control group,with statistically significant differences(all P＜0.05).The incidence of VAP in the observation group was lower than that in the control group,with a statistically significant difference(P＜0.05).Conclusion Based on the timing theory,invasive-non-invasive sequential mechanical ventilation therapy combined with high-flow oxygen therapy has the same effect as conventional therapy in mild to moderate ARDS patients,but it has obvious advantages in the duration of mechanical ventilation and the occurrence of ventilators associated pneumonia,and is worthy of clinical application.
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