Effect of high dose ambroxol hydrochloride combined with bronchoscopic treat-ment in elderly patients with severe pneumonia and influence for oxygen supply and oxygen consumption
Effect of high dose ambroxol hydrochloride combined with bronchoscopic treat-ment in elderly patients with severe pneumonia and influence for oxygen supply and oxygen consumption
Objective To investigate the effect of high dose ambroxol hydrochloride combined with bronchoscopic treatment in the elderly patients with severe pneumonia and influence for oxygen supply and oxygen consumption.Methods 80 elderly patients with severe pneumonia from January 2022 to December 2023 were divided into two groups with 40 cases in each group by the random number table.The control group were treated with conventional dose ambroxol hydrochloride,the observation group were treated with high dose ambroxol hydrochloride combined with bronchoscopic treatment.Then the therapeutic effect(total effective rates),severe infection markers(CRP,IL-6 and IL-17),oxygen supply indexes(DO2 and DO2I)and oxygen consumption indexes(VO2 and VO2I)before and af-ter the treatment of two groups were compared.Results The therapeutic effect(total effective rate)of observation group was signifi-cantly better than that of control group,the difference was statistically significant(P＜0.05).The severe infection markers,oxygen sup-ply indexes and oxygen consumption indexes of two groups before the treatment were compared,the differences were not statistically sig-nificant(all P＞0.05).The severe infection markers of observation group at third and seventh day after the treatment were significantly lower than those of control group,the oxygen supply indexes and oxygen consumption indexes of observation group at first,third and sev-enth day after the treatment were significantly higher than those of control group,the differences were all statistically significant(all P＜0.05).Conclusion The high dose ambroxol hydrochloride combined with bronchoscopic treatment in the elderly patients with se-vere pneumonia is relatively better,and it can more effectively improve the oxygen supply and oxygen consumption state of patients,so its application value in the ederly patients with severe pneumonia is relatively higher.
关键词
大剂量/常规剂量/盐酸氨溴索/支气管镜/老年重症肺炎/氧供/氧耗
Key words
High dose/Conventional dose/Ambroxol hydrochloride/Bronchoscopic treatment/Elderly patients with severe pneumo-nia/Oxygen supply/Oxygen consumption
维普
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