肾移植术后发生糖尿病的影响因素
Influencing factors of diabetes after kidney transplantation
陆婷 1王雪静 2谭若芸 2彭宇竹3
作者信息
- 1. 南京医科大学公共卫生学院(南京,211112);南京医科大学第一附属医院泌尿外科
- 2. 南京医科大学第一附属医院泌尿外科
- 3. 南京医科大学公共卫生学院(南京,211112)
- 折叠
摘要
目的:探讨肾移植术后 1 年糖尿病的发生率及影响因素.方法:回顾性分析 2016 年 1 月至 2020年 12 月南京医科大学第一附属医院肾移植中心 347 例术前无糖尿病的肾移植受者的临床资料,统计移植术后糖尿病(PTDM)发生率,采用单因素和多因素Logistic回归分析方法分析PTDM发生的影响因素.结果:347 例术前无糖尿病的肾移植受者中,术后 1 年发生PTDM 79 例(22.8%).单因素分析显示,受者移植年龄(OR=1.034)、活体供肾(OR=0.178)、术前空腹血糖(OR=1.412)、术后服用环孢素A(OR=0.377)、他克莫司(OR=2.244)是术后 1 年发生PTDM的影响因素(P＜0.05),多因素分析显示,移植年龄和术前空腹血糖是术后 1 年发生PTDM发生的独立危险因素(P＜0.05).结论:术后 1 年发生PTDM与受者移植年龄、活体供肾、术前空腹血糖、服用环孢素A和他克莫司密切相关.
Abstract
Objective:To investigate the incidence and influencing factors of diabetes mellitus(PTDM)one year after renal transplantation.Methodology:Retrospective analysis was made on the clinical data of 347 renal transplant recipients without diabetes before operation in the Renal Transplantation Center of the First Affiliated Hospital of Nanjing Medical University from January 2016 to December 2020.Calculate the incidence of PTDM and analyze the influencing factors of PTDM using univariate and multivariate logistic regression analysis methods.Results:Among 347 renal transplant recipients without diabetes before operation,79 cases had PTDM one year after operation(22.8%).Univariate analysis showed that transplant age(OR= 1.034),living donor kidney(OR= 0.178),preoperative fasting blood glucose(OR = 1.412),postoperative cyclosporine(OR = 0.377),and tacrolimus(OR = 2.244)were the influencing factors for PTDM occurrence one year after kidney transplantation(P＜0.05).Multivariate analysis showed that transplant age and preoperative fasting blood glucose were independent risk factors for PTDM occurrence one year after kidney transplantation(P＜0.05).Conclusion:The occurrence of PTDM one year after kidney transplantation is closely related to the recipient's transplant age,living donor kidney,preoperative fasting blood glucose,and the use of cyclosporine and tacrolimus.
关键词
肾移植/移植后糖尿病/影响因素Key words
kidney transplantation/post-transplant diaetes mellitus/influencing factors引用本文复制引用
出版年
2024
NETL
NSTL
万方数据