单克隆免疫球蛋白病机体免疫微环境研究进展
Immune microenvironment of monoclonal gammopathy
徐维玮 1黄湘华1
作者信息
- 1. 东部战区总医院 国家肾脏疾病临床医学研究中心(南京,210016)
- 折叠
摘要
单克隆免疫球蛋白疾病以克隆性浆细胞的增殖和单克隆免疫球蛋白的产生为特点,包括系统性轻链型淀粉样变性、多发性骨髓瘤、具有肾脏意义的单克隆免疫球蛋白病及这类疾病前期的意义未明的单克隆免疫球蛋白病等.这类疾病多累及肾脏.免疫微环境在单克隆免疫球蛋白病发病调控环节中发挥着重要作用.免疫细胞如T细胞、B细胞、单核巨噬细胞、自然杀伤细胞、树突状细胞及骨髓来源的抑制细胞等,与克隆性浆细胞之间存在着密切的相互作用,调节克隆性浆细胞的清除、免疫微环境与变异浆细胞的动态平衡及最终克隆性浆细胞的免疫逃逸,进而调控疾病进程.本文对单克隆免疫球蛋白病的机体免疫微环境调控机制及已有的治疗靶点进行总结,以助力探索这类疾病未来诊治的新方向.
Abstract
Monoclonal gammopathy is a group of diseases characterized as clonal plasma cell proliferation and monoclonal immunoglobin secretion.This kind of diseases include systemic light chain amyloidosis,multiple myeloma,monoclonal gammopathy of renal significance and monoclonal gammopathy of undetermined significance which was considered as the previous stage of these diseases.Kidney is frequently involved in these diseases.Immune microenvironment plays an important role in the emergence and progression of these diseases.Immune cells such as T cells,B cells,monocytes and macrophages,natural killer cells,dendritic cells and myeloid-derived suppressor cells interact with clonal plasma cells,thereby regulate the clearance of these plasma cells,maintain the balance of immune microenvironment and plasma cells,and the immune evasion of clonal plasma cells.We are going to review the immune microenvironment and the therapies targeted the immune system in monoclonal gammopathy.
关键词
单克隆免疫球蛋白病/系统性轻链型淀粉样变性/多发性骨髓瘤/免疫微环境/治疗Key words
monoclonal gammopathy/systemic light chain amyloidosis/multiple myeloma/immune microenvironment/treatment引用本文复制引用
基金项目
国家自然科学基金面上项目(82270767)
出版年
2024
NETL
NSTL
万方数据