Iron transport disorder is a common cause of refractory anemia in chronic kidney disease(CKD)patients.Hepcidin is a key hormone for the body to maintain iron homeostasis,and it can regulate iron metabolism into the negative direction.This feedback regulation process is regulated by multiple pathways,including bone morphogenetic protein(BMP)/Smad signaling pathway,Janus kinase(JAK)/signal transducer and activator of transcription 3(STAT3)pathway,inflammation,erythropoiesis,hypoxia,etc.Hepcidin is the main target for the treatment of iron metabolism imbalance in clinical practice.In recent years,a variety of hepcidin regulation-related drugs have appeared oriented and abroad.Among them,hypoxia-inducible factor prolyl hydroxylase inhibitors(HIF-PHI)drugs such as Roxadustat are believed to effectively reduce the expression of hepcidin,increase serum iron levels,promote iron utilization,and promote red blood cell production to treat anemia in CKD patients.
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