腹膜转运功能的分子遗传学机制
Molecular genetic mechanism of peritoneal transport function
姚佳妮 1沈茜1
作者信息
- 1. 国家儿童医学中心复旦大学附属儿科医院肾脏科(上海,201102)
- 折叠
摘要
腹膜透析是终末期肾病的治疗方式之一,其利用腹膜的半透膜特性,通过腹腔透析液不断地更换,清除体内代谢产物及纠正水、电解质平衡紊乱.近来研究表明,多种分子的基因多态性均与腹膜功能相关,从而影响透析患者的预后,其对透析患者的处方及预后具有提示性意义.本文旨在阐述目前腹膜转运功能相关的分子遗传学机制的研究进展.
Abstract
Peritoneal dialysis(PD)is one of the treatment methods for end-stage kidney disease.It uses the semipermeable membrane characteristics of the peritoneum to remove metabolites in the body and correct the imbalance of water and electrolyte through continuous replacement of peritoneal dialysate.Recent studies have shown that polymorphisms of multiple molecules are correlated with peritoneal function,thereby affecting the prognosis of patients,which has suggestive significance for the prescription and prognosis of dialysis patients.The purpose of this article is to review the current research progress of molecular genetic mechanism related to peritoneal transport function.
关键词
腹膜透析/腹膜功能/分子多态性Key words
peritoneal dialysis/peritoneal ultrafiltration/molecular genetic mechanism引用本文复制引用
出版年
2024
NETL
NSTL
万方数据