Serum β-catenin and abdominal aortic calcification in maintenance hemodialysis patients
Objective:To investigate the relationship between serum β-catenin level and abdominal aortic calcification(AAC)in maintenance hemodialysis(MHD)patients.Methodology:A total of 70 MHD patients in our hospital were selected and AAC was detected using lateral abdominal plain film.According to the CORD grouping method,the patients were divided into three groups:no or mild calcification group,moderate calcification group and severe calcification group.Serum β-catenin level was detected by ELISA,and the relationship between serum β-catenin level and AAC score(AACS),demographic characteristics and biochemical indexes of MHD patients was observed.Results:The incidence of AAC in MHD patients was 70％.The serum β-catenin level of severe abdominal aortic calcification group was significantly higher than that of moderate,no or mild calcification group,and the difference was statistically significant(P＜0.05).The serum β-catenin level in moderate calcification group was also higher than that in no or mild calcification group(P＜0.05).Correlation analysis showed that serum β-catenin level was positively correlated with AACS,dialysis age,parathyroid hormone and blood phosphorus in MHD patients.Logistic regression analysis showed that the increase of β-catenin level,high body mass index and high CRP level were independent risk factors for AAC in MHD patients(P＜0.05),while the increase of serum albumin level was a protective factor(P＜0.05).The area under the curve(AUC)of serum β-catenin predicted AAC was 0.864(95％CI 0.766～0.961,P=0.000),the Yoden index was 0.693,corresponding to the serum β-catenin level was 211.63pg/ml,the sensitivity of AAC prediction was 91.70％,the specificity was 77.60％.Conclusion:The increase of serum β-catenin in MHD patients may be related to AAC.
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