Assessment of the safety and prognosis of kidney transplantation from infected donors
Objective:To evaluate the safety of using kidneys from infected donors for transplantation and the prognosis of recipients who develop postoperative infections.Methodology:Clinical data from donors and their corresponding kidney transplant recipients at the organ transplantation center of Affiliated Hospital of Zunyi Medical University from August 2014 to April 2021 were collected.Recipients were first divided into two groups based on whether the donor had an infection:the infected donor group(DI)and the non-infected donor group(DNI).The complication rates and human/kidney survival rates of the two groups were compared to assess the safety of kidneys from infected donors.Subsequently,all recipients included in the study were divided into two groups based on whether they developed an infection postoperatively:the recipient infection group(RI)and the recipient non-infection group(RNI).The prognosis of these two groups was analyzed.Results:A total of 83 donor data were collected,among which 32 cases(38.55%)were from infected donors.There was no statistical difference in the postoperative complication rates and human/kidney survival rates between the DI and DNI groups.There were no significant differences in overall clinical characteristics and prognosis between the RI group(18 cases)and the RNI group(117 cases),but the RI group had significantly higher incidences of delayed graft function(DGF)and surgical site wound non-healing,with statistical significance(P＜0.05).Conclusion:Kidneys from infected donors are safe for transplantation.Recipients who develop postoperative infections have a significantly higher incidence of DGF and surgical site wound non-healing compared to those without infections,but their overall prognosis shows no significant difference.
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