Ferroptosis in the progression from acute kidney injury to chronic kidney disease
Acute kidney injury(AKI)is an acute and critical illness with high morbidity and mortality.In recent years,a growing body of studies have shown that renal maladaptation following AKI results in chronic kidney disease(CKD).Ferroptosis,a novel form of non-apoptotic cell death characterized by iron overload and lipid peroxidation,is believed to play a significant role in the progression of AKI to CKD.This article provides a review of the classical regulatory mechanisms of ferroptosis and its potential involvement in the pathological mechanisms in the progression of AKI to CKD.
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