铁死亡在急性肾损伤进展为慢性肾脏病中的作用
Ferroptosis in the progression from acute kidney injury to chronic kidney disease
丁文庆 1马洪闯 2罗群2
作者信息
- 1. 宁波大学医学部(宁波,315211)
- 2. 宁波市第二医院肾内科
- 折叠
摘要
急性肾损伤(AKI)是临床常见的急危重症,发病率高、死亡率高.近年来研究表明,AKI后的肾脏适应不良性修复可导致慢性肾脏病(CKD).铁死亡是一种新型的非凋亡形式的细胞死亡方式,其特征是铁过载和脂质过氧化,在AKI向CKD的进展中发挥重要作用.本文就铁死亡的经典调控机制及其在AKI进展为CKD中参与的病理机制作一综述.
Abstract
Acute kidney injury(AKI)is an acute and critical illness with high morbidity and mortality.In recent years,a growing body of studies have shown that renal maladaptation following AKI results in chronic kidney disease(CKD).Ferroptosis,a novel form of non-apoptotic cell death characterized by iron overload and lipid peroxidation,is believed to play a significant role in the progression of AKI to CKD.This article provides a review of the classical regulatory mechanisms of ferroptosis and its potential involvement in the pathological mechanisms in the progression of AKI to CKD.
关键词
急性肾损伤/慢性肾脏病/铁死亡/炎症/纤维化Key words
acute kidney injury/chronic kidney disease/ferroptosis/inflammation/fibrosis引用本文复制引用
基金项目
浙江省宁波市共建医学重点学科(2022-S03)
浙江省公益技术应用研究计划项目(LGF22H050009)
出版年
2024
NETL
NSTL
万方数据