Examination of the Preparation Process and Quality Evaluation of Cortex Mori Formula Granules Based on Multiple Indicators
Abstrat:Taking Cortex Mori as the main research object,its extraction process was optimized through single factor and orthogonal experiment in three aspects:material-liquid ratio,extraction time and number,and the preparation process of Cortex Mori formula granules was optimized in two aspects:the amount of maltodextrin and the selection of wetting agent for the excipients in combination with the manufacturing process of granules.The results showed that the best extraction process of Cortex Mori by water decoction was under the material-liquid ratio of 1∶10 for 1 h and three times,which showed that the average transfer rate of Mulberroside A was 96.10%;as for the best prepa-ration process of granules,the ratio of excipients between dry extract powder and maltodextrin was 5∶1,and the wetting agent was 80%ethanol.The experiment suggests that the above-mentioned extraction and preparation processes of Cortex Mori formula granules are stable and reliable,and the quality of produced formula granules is controllable and their indexes were in accordance with the standards in Pharmacopoeia of the People's Republic of China.
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