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微生态与健康生育

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健康生育是社会之关切,微生物菌群可从各方面密切影响女性全生命周期的生殖健康.菌群失调可通过调控机体炎症、免疫及代谢等过程,导致或加重生殖内分泌疾病、不孕症、肿瘤、不良妊娠结局等,甚至影响子代健康.本文重点关注生殖道及肠道菌群对女性全生命周期的生殖健康影响,以期从菌群角度更好地了解女性健康.未来,深入解析菌群平衡和稳态对健康生育的预防和保护机制,对推动生殖障碍疾病的诊疗具有重要意义.通过菌群干预手段,建立生殖障碍疾病诊治新策略的临床转化体系,对提高生育全周期的健康水平具有深远影响.
Microbiome and reproductive health
Reproductive health is a major concern of society.The microbial community can deeply affect the reproductive health of women throughout their entire life cycle from various aspects.The imbalance of microbial can lead to reproductive endocrine diseases,infertility,tumors,adverse pregnancy outcomes,and even affect the health of offspring by regulating the body's inflammation,immunity and metabolism.This article focused on the effects of reproductive tract and intestinal flora on female reproductive health during the whole life cycle in order to better understand female health from the perspective of microbial.In the future,in-depth analysis of the prevention and protection mechanism of microbial balance and homeostasis on reproductive health is of great significance to promote the diagnosis and treatment of reproductive disorders.The establishment of a clinical transformation system of new strategies for the diagnosis and treatment of reproductive disorders by means of microbial intervention has a profound impact on improving the health level of the whole reproductive cycle.

Reproductive healthMicroecologyReproductive tract microbiotaIntestinal flora

乔杰

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北京大学第三医院妇产科 女性生育力促进全国重点实验室 国家妇产疾病临床医学研究中心,北京 100191

生殖健康 微生态 生殖道菌群 肠道菌群

国家自然科学基金基础科学中心项目

82288102

2024

中华生殖与避孕杂志
上海计划生育科学研究所

中华生殖与避孕杂志

CSTPCD北大核心
影响因子:0.989
ISSN:2096-2916
年,卷(期):2024.44(1)
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