Interactions between gut microbiota and the etiology of early spontaneous abortion
Gut microbiota plays an important role in maintaining metabolic homeostasis as well as the occurrence and development of metabolic diseases in the host.Physiological and pathological processes such as body metabolism and immune regulation are impacted by the interaction of metabolites of gut microbiota with the host.Early spontaneous abortion is one of the most common pregnancy complications,accounting for 10%-15%of all clinical pregnancies.According to the previous studies,gut microbiota had an important effect in the pathophysiological process of pregnancy complications and was expected to be a new candidate for clinical prevention and treatment of early spontaneous abortion.While the correlation between early spontaneous abortion and gut microbiota has gained attention,further investigation is needed to understand the mechanism by which the gut microbiota affects early abortion.In this review,we discussed the influence of gut microbiota on early spontaneous abortion.We found that gut microbiota may participate in the development of early spontaneous abortion by regulating human endocrine,immune functions and uterine environment,hoping to provide new ideas for clinical diagnosis and treatments.
Gut microflora dysbiosisGut microflora dysbiosisImmunomodulationEarly spontaneous abortion
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