Research progress in the treatment of intrauterine adhesions with exosomes
Exosomes,a kind of extracellular vesicles,are a research hotspot in the field of regeneration and repair in the circumstance of endometrial injury recently.Exosomes can be released by a variety of cells,and can regulate the function of receptor cells through miRNA and other bioactive substances,thus effectively promoting tissue regeneration and repair.Intrauterine adhesions(IUA)is a common endometrial injury disease resulting from uterine trauma,infection,genetic factors and other causes of damage to the endometrial basal layer.It often causes clinical problems such as abnormal menstruation,infertility and repeated abortion due to partial or total occlusion of the uterine cavity,leading to female reproductive difficulties,and the existing remedies can not achieve satisfactory repair effect concerning endometrial injuries.Therefore,recent studies have been exploring the role of exosomes in promoting endometrial repair and fertility recovery in IUA,proving the effectiveness of exosomes in repairing endometrial damage,and exploring the mechanism.Through inhibiting apoptosis,downregulating the level of epithelial-mesenchymal transition and fibrosis,facilitating cell proliferation,promoting angiogenesis,and regulating immune responses,exosomes can increase the thickness of damaged endometrium and the number of glands,and enhance endometrial receptivity and fertility,thus expected to be a new treatment for IUA in the future.Herein,we will review the research progress in the treatment of IUA with exosomes.
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