基质细胞衰老在子宫内膜蜕膜化及容受性建立中的作用机制
Potential role of stromal cell senescence in endometrial decidualization and the acquisition of endometrial receptivity
龙一婧 1齐家 1孙贇1
作者信息
- 1. 上海交通大学医学院附属仁济医院生殖医学中心 上海市辅助生殖与优生重点实验室,上海 200135
- 折叠
摘要
胚胎着床过程复杂而精密.胚胎质量、子宫内膜容受性以及两者的同步发育是决定胚胎着床的关键因素.蜕膜化是子宫内膜基质细胞转变为分泌型的蜕膜基质细胞的过程,与子宫内膜容受性密切相关.异常蜕膜化可导致胚胎着床失败或不良妊娠结局.最新研究表明子宫内膜蜕膜化中存在子宫内膜基质细胞衰老的现象,一定程度的基质细胞衰老促进蜕膜化和容受性建立,而过度或不足的基质细胞衰老则可能导致蜕膜化异常和容受性受损.本文旨在对基质细胞衰老在子宫内膜蜕膜化及容受性建立中的作用进行综述,以期为容受性相关疾病的发病机制和治疗提供新的启示.
Abstract
Embryo implantation is a complicated and elaborately regulated process.Embryo quality,endometrial receptivity and synchronized embryo-endometrium development are key determinants for embryo implantation.Decidualization refers to the differentiation of endometrial stromal cells into decidual stromal cells with a specific secretory phenotype and is closely related to endometrial receptivity.Abnormal decidualization results in implantation failure or adverse pregnancy events.Recent studies have revealed that endometrial stromal cell senescence takes place in endometrial decidualization.While moderate stromal cell senescence promotes endometrial decidualization and the establishment of endometrial receptivity,excessive or deficient stromal cell senescence could lead to abnormal decidualization and impaired receptivity.This review aims to summarize the potential role of stromal cell senescence in endometrial decidualization and the acquisition of endometrial receptivity to provide new insights in the pathogenesis and treatment of receptivity-associated diseases.
关键词
胚胎植入/细胞衰老/子宫内膜/蜕膜化/子宫内膜容受性Key words
Embryo implantation/Cellular senescence/Endometrium/Decidualization/Endometrial receptivity引用本文复制引用
基金项目
国家自然科学基金重点项目(82130046)
国家自然科学基金重点项目(81901550)
科技部重点专项(2019YFA0802604)
上海交通大学医学院高水平创新团队激励计划-协同创新团队(SHSMU-ZLCX20210201)
上海市领军人才计划(2018年)()
上海市科委扬帆计划(19YF1428300)
出版年
2024
NETL
NSTL
万方数据