首页|基质细胞衰老在子宫内膜蜕膜化及容受性建立中的作用机制

基质细胞衰老在子宫内膜蜕膜化及容受性建立中的作用机制

扫码查看
胚胎着床过程复杂而精密.胚胎质量、子宫内膜容受性以及两者的同步发育是决定胚胎着床的关键因素.蜕膜化是子宫内膜基质细胞转变为分泌型的蜕膜基质细胞的过程,与子宫内膜容受性密切相关.异常蜕膜化可导致胚胎着床失败或不良妊娠结局.最新研究表明子宫内膜蜕膜化中存在子宫内膜基质细胞衰老的现象,一定程度的基质细胞衰老促进蜕膜化和容受性建立,而过度或不足的基质细胞衰老则可能导致蜕膜化异常和容受性受损.本文旨在对基质细胞衰老在子宫内膜蜕膜化及容受性建立中的作用进行综述,以期为容受性相关疾病的发病机制和治疗提供新的启示.
Potential role of stromal cell senescence in endometrial decidualization and the acquisition of endometrial receptivity
Embryo implantation is a complicated and elaborately regulated process.Embryo quality,endometrial receptivity and synchronized embryo-endometrium development are key determinants for embryo implantation.Decidualization refers to the differentiation of endometrial stromal cells into decidual stromal cells with a specific secretory phenotype and is closely related to endometrial receptivity.Abnormal decidualization results in implantation failure or adverse pregnancy events.Recent studies have revealed that endometrial stromal cell senescence takes place in endometrial decidualization.While moderate stromal cell senescence promotes endometrial decidualization and the establishment of endometrial receptivity,excessive or deficient stromal cell senescence could lead to abnormal decidualization and impaired receptivity.This review aims to summarize the potential role of stromal cell senescence in endometrial decidualization and the acquisition of endometrial receptivity to provide new insights in the pathogenesis and treatment of receptivity-associated diseases.

Embryo implantationCellular senescenceEndometriumDecidualizationEndometrial receptivity

龙一婧、齐家、孙贇

展开 >

上海交通大学医学院附属仁济医院生殖医学中心 上海市辅助生殖与优生重点实验室,上海 200135

胚胎植入 细胞衰老 子宫内膜 蜕膜化 子宫内膜容受性

国家自然科学基金重点项目国家自然科学基金重点项目科技部重点专项上海交通大学医学院高水平创新团队激励计划-协同创新团队上海市领军人才计划(2018年)上海市科委扬帆计划

82130046819015502019YFA0802604SHSMU-ZLCX2021020119YF1428300

2024

中华生殖与避孕杂志
上海计划生育科学研究所

中华生殖与避孕杂志

CSTPCD北大核心
影响因子:0.989
ISSN:2096-2916
年,卷(期):2024.44(1)
  • 3