Research on embryo development and clinical pregnancy outcomes in patients with ovarian hyperstimulation syndrome
Objective To investigate the embryo development and clinical pregnancy outcomes in patients with ovarian hyperstimulation syndrome(OHSS)undergoing assisted reproductive technology(ART).Methods A retrospective cohort study was conducted on data from 4 080 cycles of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer treatments performed at the Department of Obstetrics and Gynecology,the First Affiliated Hospital of Anhui Medical University from August 2019 to August 2021.Patients were divided into OHSS group(n= 524)and non-OHSS group(control group,n=3 556)based on whether OHSS occurred,and the OHSS group was further divided into OHSS combined with polycystic ovary syndrome(PCOS)subgroup(n=231)and OHSS combined with non-PCOS subgroup(n=293)based on the presence of PCOS.General information,embryo developmental data and clinical outcomes were compared between the two groups.Results 1)Patients in the OHSS group[(30.7±3.6)years]were younger than those in control group[(31.5±4.8)years,P<0.001],and the number of retrieved oocytes(28.2±5.7),rates of high-quality embryos[52.7%(4 982/9 463)],blastocyst formation[54.0%(5 059/9 371)],biochemical pregnancy[75.0%(393/524)],clinical pregnancy[69.5%(364/524)],and live birth[58.0%(304/524)]were significantly higher in the OHSS group than in control group[12.5±6.7,49.8%(14 042/28 204),51.4%(14 279/27 797),59.5%(2 115/3 556),54.1%(1 924/3 556),43.6%(1 550/3 556),respectively;all P<0.001].2)Patients in the OHSS combined with PCOS subgroup[(30.2±3.1)years]were younger than those in the OHSS combined with non-PCOS subgroup[(31.1±4.0)years,P=0.009],and the estradiol level[165.0(101.0,222.5)pmol/L]was higher than that in the OHSS combined with non-PCOS subgroup[141.0(81.0,202.0)pmol/L,P=0.005];rates of high-quality embryos[56.3%(2 413/4 284)],blastocyst formation[67.1%(2 846/4 239)],and high-quality blastocysts[57.7%(2 445/4 239)]were also significantly higher in the OHSS combined with PCOS subgroup than in the OHSS combined with non-PCOS subgroup[49.6%(2 569/5 179),60.3%(3 092/5 132),50.9%(2 614/5 132),respectively;all P<0.001].Conclusion There is a certain correlation between OHSS and female age.The occurrence of OHSS does not affect embryo development and does not increase adverse pregnancy outcomes in infertile patients.The presence of PCOS does not affect the pregnancy outcomes of OHSS patients.However,in ART,we still strive to avoid the occurrence of adverse events such as OHSS as much as possible.
NETL
NSTL
万方数据
