Research progress of common histone modification regulating trophoblast cell lineage differentiation
Placenta serves as an important organ,which determines the establishment of pregnancy and intrauterine fetal growth,as well as the complex maternal-fetal crosstalk.Different subtypes of trophoblast cells mediate the diverse functions of the placenta.During placental development,the trophectoderm-derived trophoblast stem cells differentiate into all subtypes of trophoblasts and thus maintaining the structure and function of the placenta.Histone modifications can regulate chromatin structure and gene transcription,which is involved in the establishment,maintenance and differentiation of trophoblast lineage.In this review,we systemically overview the indispensable roles of histone methylation and acetylation in trophoblast differentiation.
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