Effect of the salt intake levels on clinical outcomes of the first transfer cycle in women undergoing assisted reproductive technology
Objective To explore the effect of different salt intake levels on clinical outcomes after the first embryo transfer in women undergoing assisted reproductive technology.Methods This was a retrospective cohort study.A total of 163 patients with the first in vitro fertilization/intracytoplasmic sperm injection and embryo transfer from January 2021 to July 2021 in Reproductive Medical Center,Henan Provincial People's Hospital were recruited.The spot urine method was used to estimate the 24 h salt intake of patients,and all patients were divided into three groups based on their 25th and 75th percentiles:low-salt group(≤9.21 g,n=41),medium-salt group(9.22-13.31 g,n=81),and high-salt group(≥13.32 g,n=41).Baseline data and clinical outcomes were analyzed and compared among the three groups.Results The rate of MII oocyte[72.7%(410/564)],and the rate of high-quality embryos[42.1%(109/259)]in the high-salt group were lower than those in the low-salt group[82.5%(461/559),P<0.05;52.4%(154/294),P<0.05],the differences among the three groups were statistically significant(P<0.001,P=0.048).The rate of normal cleavage[99.1%(568/573)]in the medium-salt group was higher than that in the low-salt group[96.1%(294/306),P<0.05],and the difference among the three groups was statistically significant(P=0.003).After adjusting for potential confounding factors by using multivariate logistic regression,the clinical pregnancy rate(OR=0.520,95%CI:0.221-1.221,P=0.133),the early miscarriage rate(OR=1.226,95%CI:0.219-6.851,P=0.817),and the live birth rate(OR=0.730,95%CI:0.323-1.647,P=0.448)in the medium-salt group,the clinical pregnancy rate(OR=0.659,95%CI:0.246-1.762,P=0.406),the early miscarriage rate(OR=1.080,95%CI:0.162-7.180,P=0.937),and the live birth rate(OR=1.012,95%CI:0.396-2.588,P=0.980)in the high-salt group were comparable with the low-salt group(all P>0.05).Conclusion High level of salt intake does not affect the clinical pregnancy outcomes of infertile women in their first transplantation cycle.However,it has an adverse effect on oocyte maturation,normal cleavage,and high-quality embryo formation.
Fertilization in vitroEmbryo transferSalt intakeSpot urine method
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