首页|女性性功能障碍与性激素相关性的多中心横断面研究

女性性功能障碍与性激素相关性的多中心横断面研究

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目的 探讨内源性性激素与女性性功能的相关性.方法 本研究是一项队列研究的基线数据,纳入2020年4月至2021年3月期间在首都医科大学附属北京妇产医院、北京市朝阳区妇幼保健院、北京市朝阳区太阳宫社区卫生服务中心就诊符合标准的711例女性,收集社会人口学资料(根据学历分为高中及以上、高中以下;根据婚姻关系分为满意、一般、不满意)和检测血清性激素水平.采用女性性功能指数(female sexual function index,FSFI)量表评估女性性功能.根据生殖衰老研讨会+10(Stages of Reproductive Aging Workshop+10,STRAW+10)分期系统标准将研究对象分为生育期(R)组、绝经过渡期(T)组,绝经后期(P)组.Spearman秩相关分析和多元线性回归分析确定FSFI及其各维度分数与血清性激素水平之间的相关性.结果 多元线性回归分析显示,FSFI总分与绝经后期、高中以下学历、婚姻关系一般、婚姻关系不满意呈显著负相关(均P<0.01).除疼痛评分外,高中以下学历、婚姻关系一般或不满意与FSFI中其他5个维度得分均呈负相关(均P<0.05);绝经后期与阴道润滑、性满意度和性交疼痛呈负相关(均P<0.05).内源性性激素中的卵泡刺激素与所有FSFI得分均呈负相关(均P<0.05);除性高潮和性满意度外,雌二醇与FSFI中其他4个维度得分呈正相关(均P<0.05);总睾酮与FSFI总分和性欲得分呈正相关(均P<0.05);游离睾酮与性高潮得分呈正相关(P<0.05).结论 雌二醇和总睾酮是女性性功能的保护因素.
A multicentre cross-sectional study on the correlation of female sexual dysfunction with sex hormones
Objective To explore the correlation between endogenous sex hormone factors and sexual function in Chinese women.Methods A total of 711 women who met the criteria were investigated in the Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Chaoyang District Maternal and Child Health Care Hospital,Beijing Chaoyang District Taiyanggong Community Health Service Centre from April 2020 to March 2021.Sociodemographic data(data split into two groups according to educational background:high school or above and lower high school;and three categories based on marital relationship:satisfied,average,and dissatisfied)and serum levels of sex hormones were collected.Female sexual dysfunction(FSD)was evaluated using the female sexual function index(FSFI).Participants were divided into three groups according to the Stages of Reproductive Aging Workshop(STRAW+10):reproductive stage group,menopausal transition stage group and postmenopausal stage group.Spearman rank correlation analysis and multiple linear regression analyses were performed to determine the correlation between characteristics and scores of FSFI.Results The multivariate logistic regression analysis revealed that postmenopausal stage,secondary education level,neutral and dissatisfied marital relations were significantly negatively correlated with total FSFI score(all P<0.01).Secondary education level,neutral and dissatisfied marital relations were negatively associated with nearly all FSFI domains apart from pain score(all P<0.05);postmenopausal stage was negatively associated with lubrication,satisfaction and pain(all P<0.05).FSH was negatively associated with all FSFI domain scores(all P<0.05).There was a significantly positive correlation between estradiol and scores of FSFI dimensions other than orgasm and satisfaction(all P<0.05).Total testosterone positively affected the score of total FSFI and desire(all P<0.05);free testosterone was positively related to orgasm(P<0.05).Conclusion Estradiol and total testosterone serve as protective factors for female sexual function.

MenopauseSex hormonesFemale sexual dysfunctionSexual function indexStaging of reproductive aging

鞠蕊、阮祥燕、代荫梅、杨瑜、许新、程姣姣、白勇涛、施琰红、杨幸子、孙艳华、李瑞玲、Alfred O. Mueck

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首都医科大学附属北京妇产医院 北京妇幼保健院药物临床试验机构办公室,北京 100026

首都医科大学附属北京妇产医院 北京妇幼保健院内分泌科,北京 100026

北京市朝阳区太阳宫社区卫生服务中心妇科,北京 100028

北京市朝阳区妇幼保健院妇科,北京 100022

德国图宾根大学妇产医院妇女健康部与妇女健康研究中心,图宾根 D-72076

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绝经 性激素 女性性功能障碍 性功能指数 生殖衰老分期

北京市医院管理局"登峰"计划专项中国健康促进基金会项目国家更年期保健特色专科建设单位项目北京市级妇幼保健专科示范单位更年期保健专科建设项目(第一批)

DFL20181401CHPF-2018-OP-11202030201735号

2024

10.3760/cma.j.cn101441-20230630-00256

中华生殖与避孕杂志
上海计划生育科学研究所

中华生殖与避孕杂志

CSTPCD北大核心
影响因子：0.989
ISSN：2096-2916
年,卷(期)：2024.44(3)
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