Research progress of microbiota and premature ovarian insufficiency
Premature ovarian insufficiency(POI)is characterized by the decline or loss of ovarian function before the age of 40 years and account for one major cause of female infertility.Its pathogenesis is complex.Recently,the research on microbiota and reproductive endocrine diseases has become a hot spot.This article reviews the involvement of microbiota in the occurrence and development of POI through immune response,inflammatory factors and metabolic function.At the same time,taking probiotics and fecal microbiota transplantation can correct the dysbiosis of flora,so as to improve the symptoms associated with POI.In the future,it is expected to provide new strategies for the diagnosis and treatment of POI through further research on the relationship between microbiota and POI.
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