Research advances on the relationship between Sirtuins family and reproductive aging
With the postponement of human reproductive time,studying how to intervene in reproductive system aging has become a globally significant topic.Sirtuins are NAD+-dependent histone deacetylases that play key roles in gene regulation,apoptosis,energy metabolism,age-related diseases,and the reproductive system.Current evidence suggests that deletion of the Sirtuins gene leads to developmental disorders and reproductive aging in both males and females,and that pharmacological intervention in Sirtuins expression can affect aging-induced decline in reproductive function.This review provides a comprehensive review of the effects and mechanisms of Sirtuins on male and female reproductive aging,and lists some natural drugs that can modulate Sirtuins activity,providing ideas for further studies on the regulation of reproductive aging at the molecular level.
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