Effect of Wenyang Huazhuo recipe on pregnancy outcomes in patients with unexplained recurrent spontaneous abortion
Objective To observe the effect of Wenyang Huazhuo recipe(WYHZ)on pregnancy outcomes in patients with unexplained recurrent spontaneous abortion(URSA).Methods A retrospective cohort study was used and 240 cases of pregnancy URSA patients with spleen kidney yang deficiency syndrome at the Reproductive Center,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and Department of Gynaecology and Obstetrics,General Hospital of Tianjin Medial University from November 2018 to March 2022 were recruited.The patients were assigned to WYHZ group(120 cases)and control group(120 cases)based on whether accepting oral WYHZ from 3 months before pregnancy to 8-12 weeks after pregnancy regularly.Pregnancy outcomes,perinatal period outcomes and obstetric complications were compared between the two groups.Multivariate logistic regression were used to analyze the effect of WYHZ on pregnancy outcome.Results The live birth rate and the clinical pregnancy rate in WYHZ group[86.67%(104/120),90.00%(108/120)]were higher than those in control group[71.67%(86/120),P=0.004;75.00%(90/120),P=0.002].The early abortion rate in WYHZ group[10.08%(12/119)]was lower than that in control group[25.86%(30/116),P=0.002],the differences were statistically significant.There were no significant differences in perinatal outcome and incidence rate of obstetric complications between the two groups(all P>0.05).Multivariate logistic regression analysis showed that the application of WYHZ significantly improved the live birth rate(OR=8.818,95%CI:3.556-21.871,P<0.001)and sustained pregnancy rate(OR=11.261,95%CI:4.262-29.751,P<0.001)in URSA patients.Conclusion WYHZ using before and during pregnancy can significantly improve the live birth rate and the clinical pregnancy rate of URSA patients with syndrome of yang deficiency of spleen and kidney,and improve their pregnancy outcomes.
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