Research progress in the application of round spermatid injection technology
Round spermatid is the precursor cell of mature spermatozoon with haploid genetic composition.The round sperm injection(ROSI)technology can fertilize oocytes and develop into fetuses.In 1996 the first human baby was born through ROSI technology,but the subsequent clinical practice alternates between success and failure.Until today,ROSI technology has not been widely applied in clinical practice due to its low efficiency and insufficient research on the safety of the fetus born through ROSI technology.ROSI technology has shown broad application prospects in addressing some non-obstructive azoospermia patients'reproductive biology offspring issues.This article aims to provide a review of the application research progress of ROSI technology to gain a more comprehensive and systematic understanding of ROSI technology and promote its more efficient and safe clinical application.
Round spermatid injectionReproductive technology,assistedInfertility,maleEmbryonic development
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