Role of seminal plasma in female reproductive regulation
The function of seminal plasma includes as a transport medium for sperm and as a means of communication for males to convey information to female reproductive tissues.It is an important factor in stimulating the female reproductive tract to become fertile.When the female reproductive tract exposed to seminal plasma,it occurs a violent inflammatory response,and the function of multiple female reproductive organs is changed.Increased pathogen and debris removal in the cervix and uterus can be observed during mating.Seminal plasma can also influence the activity of endometrial epithelial cells and stromal cells,thus promote the receptivity of the uterus,and establish maternal tolerance to semi-allogeneic embryos through immune cell system,providing ideal conditions for effective implantation and pregnancy of embryos.For the treatment of infertility,assisted reproductive technology has been widely used.It is possible to use seminal plasma as an adjuvant therapy to promote endometrial receptivity and regulate maternal immune tolerance,thereby improving the potential of embryo implantation and continued development during assisted reproductive therapy cycle.In this paper,the composition of seminal plasma and its physiological effects on various parts of female reproductive tract are reviewed.Meanwhile,the current clinical application of seminal plasma is reviewed as well.
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