首页|人类精子代谢和表观遗传调控通过影响精子活力导致男性不育的研究进展

人类精子代谢和表观遗传调控通过影响精子活力导致男性不育的研究进展

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精子作为男性体内高度分化的单倍体生殖细胞,是生命遗传信息传递的重要载体,其结构完整是正常受精的条件,也是正常代谢产生能量和完成表观遗传的基础.精子代谢被认为是精子运动的"供能站",保证精子发生、成熟、过活化和精卵结合等生命活动正常进行,代谢异常会直接影响精子活力造成男性不育.而精子表观遗传是一种通过父系遗传来影响后代胚胎发育和繁殖的过程,包括DNA甲基化、染色质重塑和精子携带的小RNA等多种调控方式,它们可在一定程度上影响能量产生,进而导致精子活力和男性生育力下降.因此,精子代谢和表观遗传在维持精子活力方面有着不可分割的联系,本文就人类精子结构、代谢和表观遗传调控方面进行综述,以期为与它们相关的精子活力异常导致的男性不育症相关研究提供理论参考.
Advances in the study of human sperm metabolism and epigenetic regulation causing male infertility by influencing sperm motility
As a highly differentiated haploid germ cell in male body,sperm is an important carrier of life genetic information transmission,and its structural integrity is the condition of normal insemination,and also the basis of normal metabolism to produce energy and complete epigenetic inheritance.Sperm metabolism is considered to be the"energy supply station"of sperm movement,which ensures the normal life activities such as spermatogenesis,maturation,over-activation and sperm-egg union.Abnormal metabolism will directly affect the sperm vitality and cause male infertility.Sperm epigenetic inheritance is a process that affects the embryonic development and reproduction of offspring through paternal inheritance,including DNA methylation,chromatin remodeling and small RNA carried by sperm and other regulatory modes,which can also affect energy production to a certain extent,thereby leading to the decline of sperm motility and male fertility.Therefore,sperm metabolism and epigenetics are inextricably related to the maintenance of sperm motility.In this paper,the structure,metabolism and epigenetic regulation of human sperm are reviewed in order to provide theoretical reference for the research on male infertility caused by abnormal sperm motility.

Oxidative phosphorylationReactive oxygen speciesHistoneDNA methylationSperm metabolism

孙非凡、张茂翔、姜昱、王纳、任发、乔鹏云

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潍坊医学院附属医院(临床医学院),潍坊 261042

潍坊医学院附属医院生殖医学中心,潍坊 261041

氧化磷酸化 活性氧 组蛋白 DNA甲基化 精子代谢

山东省自然科学基金山东省中医药科技项目吴阶平医学基金会科研专项潍坊市卫生健康委项目潍坊医学院附属医院种子计划

ZR2022QC080M-2023223320.6750.2024-06-8WFWSJK-2023-3692022wyfzzjj02

2024

10.3760/cma.j.cn101441-20230730-00052

中华生殖与避孕杂志
上海计划生育科学研究所

中华生殖与避孕杂志

CSTPCD北大核心
影响因子：0.989
ISSN：2096-2916
年,卷(期)：2024.44(5)
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