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生殖药理学学科发展与挑战

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当前,生殖药理学的核心内容是发掘和研究生育力保护药物及治疗机制.随着时代的发展,生殖药理学已从早期单一的避孕药研究向生育力保护药物和治疗拓展,延伸至生殖系统疾病、生殖肿瘤以及辅助生育等交叉学科.一些新技术,如基因组学、转录组学、代谢组学、蛋白组学、类器官培养、干细胞和单细胞测序技术等的应用为生殖药理研究提供了丰富的技术手段,为揭示生育力保护药物新靶点和新机制提供了新的研究方向,极大地促进生殖药理学学科的发展.目前,我国面临着低生育率、高流产率和高龄化并存的社会特点,这给生殖药理学的发展提出了新的挑战,督促我们应更加重视生育力保护,通过发掘新的治疗机制研发适合不同人群的、安全有效的生育力保护药物和治疗方法,减少不必要的人工流产,为有意愿生育人群创造生育机会,提高生育能力,延长生育周期,保护其生育力.此外,对辅助生殖技术及其相关产品对后代健康的可能带来药理学效应和影响应予以更多的关注和研究,更好地为提高我国人口素质和生育质量服务,这既是生殖药理学面临的挑战,也是未来学科的发展方向.
Development and challenges of reproductive pharmacology
Currently,the major task of reproductive pharmacology is fertility preservation.Aside from studying the efficacy of contraceptives,the research area of reproductive pharmacology has been expanded to probe into the pharmacodynamics and the mechanism of action of medications for treatment of reproductive system disease and assisted fertility as well.The development of analysis techniques,including genomics,transcriptomics,metabolomics,proteomics,organoid culture,stem cell technology and single cell sequencing,provide multiple ways to explore therapeutic targets and new mechanisms of the treatment approaches.With the changes of age structure diagram in China population accompanied with coexisting lower fertility,higher abortion rate and increased number of seniors,more attention in the area of reproductive pharmacology should be paid on the research and development of contraceptives suitable for the young and the unmarried girls to avoid unnecessary abortion and preserve their fertility and provide more opportunities for those who willing to have children,extending their the reproductive span.Furthermore,pharmacological effects,especially the impact and outcomes of assisted reproductive technology and pertaining products on the health of the offspring should be paid more investigation and concerned,which belong to a part of the basic national policy of eugenics and are crucial to enhance the population quality of all the nationalities.This is a major challenge for the reproductive pharmacology researchers faced.

Reproductive pharmacologyFertility protectionContraceptivesHealth of offspringDiscipline progress

朱焰、张鑫、傅大煦

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上海市生物医药技术研究院 国家卫健委生育调节药械重点实验室暨上海市生殖健康工程技术中心,上海 200032

生殖药理 生育力保护 避孕节育 子代健康 学科发展

上海张江国家自主创新示范区专项发展资金重大项目计划

ZJ2022-ZD-006

2024

中华生殖与避孕杂志
上海计划生育科学研究所

中华生殖与避孕杂志

CSTPCD北大核心
影响因子:0.989
ISSN:2096-2916
年,卷(期):2024.44(6)
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