影响精子活力的生活方式、环境因素和常用药物
Lifestyles,environmental factors,and commonly used drugs affecting sperm motility
赖佳嘉 1王嫣然 1张淑微 1胡嘉怡 1朱泽宇 1李坤1
作者信息
摘要
精子活力即精子的前向运动能力,是精子核心功能之一.在自然生殖过程中,只有具备正常活力的精子才能抵达受精部位并与卵子识别融合.当前向运动精子的百分比低于参考值下限时,可诊断为弱精子症,这是男性不育的主要原因之一.精子活力的维持依赖于尾部结构和信号转导的正常运作.此外,与精子活力相关的胞外环境因素也极为关键.本综述从生活方式、环境因素和常用药物等多角度探讨影响精子活力的外界因素,旨在为弱精子症的预防与诊断提供有益线索,并为预防男性不育症提供科学依据.
Abstract
Sperm motility,a crucial function of sperm,refers to the ability of sperm to move progressively forward.Only sperm with adequate motility can reach the fertilization site and successfully recognize and fuse with an egg during natural reproduction.Asthenozoospermia,defined by a percentage of progressive sperm below the reference value's lower limit,is one of the most prevalent causes of male infertility.Sperm motility maintenance relies on both a normal flagellar structure and signal transduction pathways.However,extracellular environmental factors related to motility are also of significant importance.This review addresses factors influencing sperm motility,encompassing lifestyles,environmental elements,and commonly used drugs.It offers valuable insights for the prevention and diagnosis of asthenozoospermia and supports the strategies for preventing male infertility.
关键词
精子活力/年龄/肥胖/吸烟/饮食/温度/弱精子症/药物Key words
Sperm motility/Age/Obesity/Smoking/Diet/Temperature/Asthenozoospermia/Drug引用本文复制引用
基金项目
浙江省自然科学基金(LY22H040011)
浙江省卫生高层次创新人才培养项目(2018)()
浙江省人民医院临床基础联合项目(C-2023-YXLH11)
出版年
2024
NETL
NSTL
万方数据