Research progress on mammalian theca cells and their stem cells
Follicular theca cells not only provide support for the integrity of follicles,but also play a crucial role in follicular development,atresia,selection of dominant follicles,and ovulation.Although theca cells play an important role in female reproductive processes,research on their development,origin,and stem cells origin is currently very scarce.The study of theca stem cells not only allows us to gain a deeper understanding of the recruitment,growth,and differentiation of theca cells,but also helps us to make functional theca cells from theca stem cells.These studies will have significance impacts on the diagnosis,prevention,and treatment of human ovarian diseases,as well as regenerative medicine.This article provides a brief review of the functions,sources,and research progress of theca cells,as well as a brief introduction of the application of single-cell RNA-sequencing technology in the field of ovarian stem cell research.It provides a reference for further exploration of the mechanisms of ovarian follicle development,pathological changes,and disease treatment.
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