摘要
随着胚胎植入前遗传学检测(preimplantation genetic testing,PGT)技术应用规模不断扩大,分子遗传学检测技术在辅助生殖临床诊疗领域也得到了飞速发展和进步.PGT的稳定性、可靠性和有效性是后续胚胎精准筛选的重要保障,而实验室质量控制和管理是PGT临床应用必不可少的环节.PGT质量控制的内容可以概括为"人机料法环"和"检测前中后",这些内容覆盖了PGT技术临床应用的各个环节.为使PGT技术应用更加标准与规范化,本文就PGT的质量控制进行分析和讨论,以期为高质量临床实践提供可靠的实验室诊疗依据.
Abstract
With the increasing application scale of preimplantation genetic testing(PGT),the role of molecular genetic testing technology in the clinical diagnosis and treatment of assisted reproductive technology is also rapidly improving.The stability,reliability and validity of PGT results are important guarantees for the subsequent precise embryo screening,and laboratory quality control and management are essential for the clinical application of PGT.The content of PGT quality control can be summarized as personnel,equipment,materials,methods,environment,and pre-test,in-test and post-test,which cover all aspects of whole clinical process of PGT.In order to make clinical PGT practice more standardized,the quality management of each PGT step is analyzed and discussed in this article,so as to provide reliable laboratory diagnosis and treatment basis for high-quality clinical practice.
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