颅内生殖细胞肿瘤致青春期延迟2例并文献复习
Two cases of delayed puberty caused by intracranial germ cell tumors and literature review
许灵波 1孙晓彤 1何西彦 1蒲瑞阳 1甄璟然2
作者信息
- 1. 甘肃省人民医院产科,兰州 730000
- 2. 中国医学科学院北京协和医院妇科内分泌与生殖中心,北京 100032
- 折叠
摘要
颅内生殖细胞肿瘤(intracranial germ cell tumors,iGCT)是导致青春期延迟(delayed puberty,DP)的常见原因.本文回顾性分析2例iGCT致DP患者的临床病例资料.2例患者疾病特点包括DP、原发性闭经、生长发育迟缓、身材矮小、亚临床甲状腺功能减退等,经影像学和相关检验明确诊断为DP.在积极治疗原发病的基础上给予相应的性激素药物诱导青春期进展后,2例患者身高、体质量及第二性征有不同程度发育,目前在随诊中.尽早识别并给予适当的临床干预对于DP患者的生殖内分泌功能、骨骼健康和终身高等远期健康具有重要意义.
Abstract
Intracranial germ cell tumors(iGCT)is a common cause of delayed puberty(DP).A retrospective analysis was conducted on the clinical data of two patients with DP caused by iGCT.The disease characteristics of the two patients included DP,primary amenorrhea,growth retardation,short stature,subclinical hypothyroidism,etc.They were diagnosed as DP through imaging and related biochemical tests,and some sex hormone drugs were given on the basis of active treatment of the primary disease.Two patients had varying degrees of development in height,weight and secondary sexual characteristics,and further treatment condition is being tracking by us.Early identification and appropriate clinical intervention are of great significance to the reproductive endocrine function,bone health and long-term health such as terminal height of DP patients.
关键词
生殖细胞肿瘤/青春期延迟/性激素Key words
Germ cell tumors/Delayed puberty/Sex hormones引用本文复制引用
出版年
2024
NETL
NSTL
万方数据