Two cases of delayed puberty caused by intracranial germ cell tumors and literature review
Intracranial germ cell tumors(iGCT)is a common cause of delayed puberty(DP).A retrospective analysis was conducted on the clinical data of two patients with DP caused by iGCT.The disease characteristics of the two patients included DP,primary amenorrhea,growth retardation,short stature,subclinical hypothyroidism,etc.They were diagnosed as DP through imaging and related biochemical tests,and some sex hormone drugs were given on the basis of active treatment of the primary disease.Two patients had varying degrees of development in height,weight and secondary sexual characteristics,and further treatment condition is being tracking by us.Early identification and appropriate clinical intervention are of great significance to the reproductive endocrine function,bone health and long-term health such as terminal height of DP patients.
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