The decline of ovarian function due to aging is an irreversible natural physiological process,manifested by the progressive depletion of follicles and the decrease of oocyte quality in the ovary.Existing studies have shown that the Sirtuins family is involved in the development of ovarian aging through various pathways,such as regulation of nicotinamide adenine dinucleotide levels,oxidative stress,chromosome segregation and genomic stability.In this paper,we review the current roles of Sirtuins family proteins in ovarian aging and their molecular mechanisms.
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