巨噬细胞异常与复发性流产发病机制的研究进展
Research progress on macrophage abnormalities and the pathogenesis of recurrent spontaneous abortion
杨贾 1李莉 1王海燕1
作者信息
- 1. 北京大学第三医院妇产科生殖医学中心,北京 100191
- 折叠
摘要
复发性流产作为临床上难治的妊娠并发症,发病原因复杂.其中免疫因素的影响一直受到人们的关注.巨噬细胞,作为母-胎界面的第二大免疫细胞群,参与女性各种生殖事件,越来越多的研究提示巨噬细胞异常与复发性流产的发生密切相关.本文概括了子宫巨噬细胞的来源及分类,分别从微观层面巨噬细胞的极化异常、宏观层面巨噬细胞的功能异常系统地梳理其与复发性流产的关系,并尝试寻找该领域新的探索方向.
Abstract
Recurrent spontaneous abortion is a clinical complication of refractory pregnancy and has complex causes.Among them,the effect of immunological factors has been received much attention.Macrophages,as the second largest group of immune cells at the maternal-fetal interface,are involved in various reproductive events in women,and a growing number of studies have suggested that their abnormalities are closely related to the pathogenesis of recurrent spontaneous abortion.In this paper,we summarized the sources and classifications of uterine macrophages,systematically reviewed the relationship between the abnormal polarization of macrophages at the microscopic level,the abnormal function of macrophages at the macroscopic level and recurrent spontaneous abortion,thus attempted to find new directions of exploration in this field.
关键词
巨噬细胞/免疫/复发性流产/发病机制Key words
Macrophages/Immunity/Recurrent spontaneous abortion/Pathogenesis引用本文复制引用
基金项目
北京大学第三医院院队列建设项目(BYSYDL2022003)
出版年
2024
NETL
NSTL
万方数据