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子宫内膜容受性分子检测方法研究进展

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人类的生殖过程包含配子的生成与输送,受精卵的产生与种植,以及胚胎的发育与胎儿分娩等,任何环节的异常都有可能阻碍新生命的诞生.子宫内膜是女性生殖系统中重要的组成部分,它对于受精卵着床和胚胎发育都起着至关重要的作用.然而,传统形态学观测方法难以准确确定子宫内膜的容受状态,随着分子诊断的发展以及"组学"概念的兴起,出现了一系列新型检测技术.本文主要阐述子宫内膜容受性分子检测方法的研究进展,这些方法利用分子生物学技术对子宫内膜细胞、基因、代谢产物和微生物等方面的特征进行检测,从而更加准确地评估子宫内膜的容受状态.
Research progress on molecular detection methods of endometrial receptivity
The human reproductive process includes the generation and transport of gametes,the production and implantation of fertilized eggs,as well as the development of embryos and the birth of fetuses.Any abnormality in any of these steps may hinder the birth of new life.The endometrium is an important component of the female reproductive system,playing a crucial role in the implantation of fertilized eggs and embryo development.However,traditional morphological observation methods are difficult to accurately determine the receptive state of the endometrium.With the development of molecular diagnostics and the emergence of the concept of"omics",a series of novel detection techniques have been introduced.This article mainly elaborates on the research progress of molecular detection methods for endometrial receptivity,which use molecular biology techniques to detect characteristics of endometrial cells,genes,metabolic products,and microorganisms,aiming to more accurately evaluate the receptive state of the endometrium.

InfertilityEmbryo implantationMolecular diagnostic techniquesReproductive techniques,assistedEndometrial receptivityWindow of implantation

彭可欣、赵子菡、张慧、刘江

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昆明医科大学第一附属医院生殖遗传科,昆明 650032

不孕症 胚胎植入 分子诊断技术 生殖技术,辅助 子宫内膜容受性 种植窗

国家自然科学基金云南省"兴滇英才"支持计划云南省医学学科后备人才

81960504RLQB20200002H-2018015

2024

10.3760/cma.j.cn101441-20230816-00073

中华生殖与避孕杂志
上海计划生育科学研究所

中华生殖与避孕杂志

CSTPCD北大核心
影响因子：0.989
ISSN：2096-2916
年,卷(期)：2024.44(7)
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