非梗阻性无精子症关键基因及表观遗传因素的研究进展
Advances of key genes and epigenetic factors during spermatogenesis in non-obstructive azoospermia
侯小君 1张美姿 1徐凤琴1
作者信息
- 1. 天津市第一中心医院生殖医学科,天津 300192
- 折叠
摘要
非梗阻性无精子症(non-obstructive azoospermia,NOA)是因精子生成障碍所致的复杂性生殖系统疾病.近年来随着测序技术的广泛应用,精子发生中一些关键基因被不断挖掘.这些基因中涉及减数分裂前后变化的基因数量最多.表观遗传修饰包括DNA甲基化、组蛋白变体参与以及非编码RNA调控等.它们在多个层面反映了NOA患者的精子发生异常.本文系统地梳理了NOA中精子发生关键基因和一些表观遗传因素的最新研究动态,为NOA临床诊断的生物学标志物开发和临床诊疗方案的优化提供新思路.
Abstract
Non-obstructive azoospermia(NOA)is a complex male infertility disease with abnormal spermatogenesis.With the wide application of sequencing technology in recent years,key genes related to spermatogenesis in NOA patients have been continuously mined out.Some epigenetic factors,such as DNA methylation,histone changes and non-coding RNAs are important indicators that reflect to the heterogeneity and complexity of spermatogenesis failure in NOA.This article systematically reviewed the latest studies on the key genes and some epigenetic factors during spermatogenesis of NOA,which may prospectively help to exploit clinical biomarker and to optimize therapeutic proposals.
关键词
精子发生/基因/减数分裂/甲基化/非编码RNAKey words
Spermatogenesis/Gene/Meiosis/Methylation/Non-coding RNA引用本文复制引用
出版年
2024
NETL
NSTL
万方数据