子宫内膜异位症作为常见的妇科慢性疾病,可导致患者出现持续加重的盆腔粘连、疼痛和不孕等症状,严重影响女性的生育力和生活质量.维生素D和子宫内膜异位症的相关研究受到了越来越多的关注,而维生素D在靶器官中的作用依赖于维生素D受体(vitamin D receptor,VDR)的表达及其生物学功能.鉴此,本文总结了VDR的功能和特点,并针对VDR在子宫内膜异位症中的表达水平、基因多态性,VDR在子宫内膜异位症病理过程中的作用机制以及VDR激动剂在子宫内膜异位症治疗中的研究进展作一综述,为子宫内膜异位症诊断和治疗的基础与临床研究提供新的思路.
Research progress of vitamin D receptor in endometriosis
Endometriosis is a common chronic gynecological disease and leads to continuous aggravation of pelvic adhesion,pain and infertility,which seriously affects women's fertility and quality of life.Studies related to vitamin D and endometriosis have received increasing attention,the response of vitamin D in target organs depends on the expression level and biological function of vitamin D receptor(VDR).Thus,the function and characteristics of VDR were summarized in this study,and the expression level,gene polymorphism,mechanism of VDR in endometriosis and the research progress of VDR agonists in the treatment of endometriosis were reviewed,providing new ideas for basic and clinical research on diagnosis and treatment of endometriosis.
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