Research progress on the effects of anti-tumour chemotherapy agent on male fertility
Anti-tumour chemotherapy agents(ATCA)have been widely used in the treatment of solid tumours,haematological disorders and other oncological diseases affecting the male reproductive system.ATCA caused cellular structural damage and functional abnormalities in the testes,epididymides and accessory gonads,resulting in reduced sperm concentration,viability,normal morphology and sperm DNA integrity.ATCA also led to lower levels of testosterone and inhibin B,which affects fertility.ATCA have different adverse effects on pre-and post-pubertal male patients.This paper reviews the mechanisms of damage to the testis,epididymis and accessory gonads by ATCA and the characteristics of the effects on male reproductive system before and after puberty.
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