抗肿瘤化学药物对男性生育力影响的研究进展
Research progress on the effects of anti-tumour chemotherapy agent on male fertility
梁明洁 1王奇玲1
作者信息
- 1. 广东省生殖科学研究所男科 广东省生殖医院人类精子库 国家卫生健康委员会男性生殖与遗传重点实验室,广州 510600
- 折叠
摘要
抗肿瘤化学药物(anti-tumour chemotherapy agent,ATCA)治疗常应用于实体瘤、血液肿瘤等肿瘤疾病,同时对男性生殖系统具有损伤作用.男性接受ATCA治疗可引起睾丸、附睾及附属性腺等细胞结构损伤及功能异常,导致精子浓度和活力降低,精子正常形态率及精子DNA完整性下降,睾酮及抑制素B水平下降,造成生育力损伤,且ATCA治疗对青春期前、后男性患者损伤效应不同.本文就ATCA治疗对睾丸、附睾和附属性腺的损伤机制,及其对青春期前、后男性生殖系统的影响特征进行综述.
Abstract
Anti-tumour chemotherapy agents(ATCA)have been widely used in the treatment of solid tumours,haematological disorders and other oncological diseases affecting the male reproductive system.ATCA caused cellular structural damage and functional abnormalities in the testes,epididymides and accessory gonads,resulting in reduced sperm concentration,viability,normal morphology and sperm DNA integrity.ATCA also led to lower levels of testosterone and inhibin B,which affects fertility.ATCA have different adverse effects on pre-and post-pubertal male patients.This paper reviews the mechanisms of damage to the testis,epididymis and accessory gonads by ATCA and the characteristics of the effects on male reproductive system before and after puberty.
关键词
青春期/抗肿瘤化学药物/男性生育力Key words
Puberty/Anti-tumour chemotherapy agents/Male fertility引用本文复制引用
基金项目
广东省医学科研基金(B2023487)
广东省医学科研基金(B2023185)
出版年
2024
NETL
NSTL
万方数据