慢性子宫内膜炎影响胚胎种植的研究进展
Research progress of chronic endometritis affecting embryo implantation
石举梅 1赵晓丽 1夏天1
作者信息
- 1. 天津中医药大学第一附属医院生殖中心 国家中医针灸临床医学研究中心,天津 300193
- 折叠
摘要
慢性子宫内膜炎(chronic endometritis,CE)是导致育龄期女性不孕的重要病理因素,子宫内膜免疫-炎症稳态失衡、微生物群多样性异常是其特征性表现.CE是导致胚胎种植失败的重要因素,与内膜的慢性炎症状态影响卵泡发育、异常微生物群介导内膜免疫-代谢微环境紊乱、阻断母-胎界面信号交流、降低子宫内膜容受性等机制密切相关.本文对CE的特征性表现及其影响胚胎种植的相关机制进行综述,以期为CE合并胚胎种植失败提供治疗思路.
Abstract
Chronic endometritis(CE)is an important pathological factor leading to infertility in women of childbearing age,and its characteristic manifestations are imbalanced immune-inflammatory homeostasis and abnormal microbial diversity.CE is an important factor leading to embryo implantation failure,which is closely related to the mechanism of chronic endometrial inflammation affecting follicle development,abnormal microflora mediating endometrial immune-metabolic microenvironment disorder,blocking mother-to-fetus interface signal communication,and reducing endometrial receptivity.In this paper,the characteristics of CE and its related mechanisms affecting embryo implantation were reviewed in order to provide therapeutic ideas for CE combined with embryo implantation failure.
关键词
慢性子宫内膜炎/胚胎种植/子宫内膜容受性/母胎交流Key words
Chronic endometritis/Embryo implantation/Endometrial receptivity/Maternal-fetal communication引用本文复制引用
出版年
2024
NETL
NSTL
万方数据