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慢性子宫内膜炎影响胚胎种植的研究进展

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慢性子宫内膜炎(chronic endometritis,CE)是导致育龄期女性不孕的重要病理因素,子宫内膜免疫-炎症稳态失衡、微生物群多样性异常是其特征性表现.CE是导致胚胎种植失败的重要因素,与内膜的慢性炎症状态影响卵泡发育、异常微生物群介导内膜免疫-代谢微环境紊乱、阻断母-胎界面信号交流、降低子宫内膜容受性等机制密切相关.本文对CE的特征性表现及其影响胚胎种植的相关机制进行综述,以期为CE合并胚胎种植失败提供治疗思路.
Research progress of chronic endometritis affecting embryo implantation
Chronic endometritis(CE)is an important pathological factor leading to infertility in women of childbearing age,and its characteristic manifestations are imbalanced immune-inflammatory homeostasis and abnormal microbial diversity.CE is an important factor leading to embryo implantation failure,which is closely related to the mechanism of chronic endometrial inflammation affecting follicle development,abnormal microflora mediating endometrial immune-metabolic microenvironment disorder,blocking mother-to-fetus interface signal communication,and reducing endometrial receptivity.In this paper,the characteristics of CE and its related mechanisms affecting embryo implantation were reviewed in order to provide therapeutic ideas for CE combined with embryo implantation failure.

Chronic endometritisEmbryo implantationEndometrial receptivityMaternal-fetal communication

石举梅、赵晓丽、夏天

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天津中医药大学第一附属医院生殖中心 国家中医针灸临床医学研究中心,天津 300193

慢性子宫内膜炎 胚胎种植 子宫内膜容受性 母胎交流

国家自然科学基金

82205172

2024

中华生殖与避孕杂志
上海计划生育科学研究所

中华生殖与避孕杂志

CSTPCD北大核心
影响因子:0.989
ISSN:2096-2916
年,卷(期):2024.44(10)
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