未折叠蛋白反应与女性生殖障碍的研究进展
Research progress on the unfolded protein response and female reproductive disorders
孟一闻 1朱琴玲 1孙贇1
作者信息
- 1. 上海交通大学医学院附属仁济医院生殖医学中心 上海市辅助生殖与优生重点实验室,上海 200135
- 折叠
摘要
内质网与线粒体在面对应激刺激下产生的未折叠蛋白或错误折叠蛋白时,会诱发未折叠蛋白反应以调控并维持细胞稳态.近年来研究表明未折叠蛋白反应在女性生殖障碍疾病发生发展发挥关键作用.本文旨在深入探讨内质网与线粒体未折叠蛋白反应的具体信号通路途径,并总结其对女性正常生殖生理过程及常见生殖障碍疾病的影响,以期能为相关疾病的诊疗提供全新潜在治疗靶点.
Abstract
The unfolded protein response is triggered by the presence of unfolded or misfolded proteins in the endoplasmic reticulum and mitochondria,aiming to regulate and maintain cellular homeostasis under stress stimuli.Recent studies have shown that unfolded protein response plays a crucial role in the pathogenesis of female reproductive-related diseases.This article delves into the specific signaling pathways of unfolded protein response in the endoplasmic reticulum and mitochondria and summarizes its impact on the physiological functions and common diseases of the female reproduction,trying to provide novel potential therapeutic targets for the diagnosis and treatment of reproductive disorder related diseases.
关键词
内质网/线粒体/未折叠蛋白反应/生殖系统Key words
Endoplasmic reticulum/Mitochondria/Unfolded protein response/Reproductive system引用本文复制引用
基金项目
国家自然科学基金重点项目(82130046)
科技部重点研发计划(2019YFA0802604)
上海交通大学医学院附属仁济医院临床科研创新培育基金计划(RJPY-DZX-003)
出版年
2024
NETL
NSTL
万方数据