Advances in genetic factors of ICSI fertilization failure due to the deficiency of sperm-borne oocyte activation factor
Fertilization is a complex biological process,in which any abnormality will lead to the occurrence of fertilization failure.Although the emergence of intracytoplasmic sperm injection(ICSI)technology has greatly improved infertility caused by male sperm factors,clinicians still encounter the problem of some unexplained ICSI fertilization failure.With the development of genetic testing technology,clinical researchers have identified pathogenic gene mutations such as PLCZ1,ACTL7A,ACTL9,IQCN in patients associated with the deficiency of sperm-borne oocyte activation factor(SOAF).However,there is currently a lack of a systematic summary of such fertilization failure.Here,we will provide a systematic review of genetic factors and treatment methods of SOAF deficiency leading to ICSI fertilization failure.
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