巨噬细胞极化在卵巢衰老中的研究进展
Research progress of macrophage polarization in ovarian aging
李丹萍 1鞠文涵 1连方 2相珊1
作者信息
- 1. 山东中医药大学第一临床医学院,济南 250014
- 2. 山东中医药大学附属医院中西医结合生殖与遗传中心,济南 250011
- 折叠
摘要
巨噬细胞是卵巢中最丰富的免疫细胞,参与机体先天免疫应答过程,在卵泡生成、排卵、黄体形成和消退等卵巢生理过程以及维持卵巢稳态中发挥重要作用.巨噬细胞可以极化为M1/M2型,可在卵巢衰老微环境中响应衰老特定的信号,参与卵巢衰老过程,对卵巢衰老发挥不同的作用.本文分别从巨噬细胞极化调控通路,巨噬细胞在正常卵巢功能中的生理作用,以及巨噬细胞极化在卵巢衰老中的影响等方面进行综述.
Abstract
Macrophages are the most abundant immune cells in the ovary.They participate in the innate immune response and play an important role in ovarian physiological processes such as follicle formation,ovulation,luteal formation and regression,as well as in maintaining ovarian homeostasis.Macrophages can be polarized into M1/M2 type,which can respond to senescence specific signals in the ovarian aging microenvironment,participate in the ovarian aging process,and play different roles in ovarian aging.This article reviews the polarization regulation pathway of macrophages,the physiological role of macrophages in normal ovarian function,and the impact of macrophage polarization on ovarian aging.
关键词
炎症/卵巢衰老/卵巢储备/巨噬细胞极化/调控通路Key words
Inflammation/Ovarian senescence/Ovarian reserve/Macrophage polarization/Regulating pathways引用本文复制引用
基金项目
山东省自然科学基金(ZR2023MH112)
中国博士后科学基金(2021M702044)
国家自然科学基金(81974577)
出版年
2024
NETL
NSTL
万方数据