外泌体在胚胎植入中的作用
Research progress in the role of exosomes in embryo implantation
王祎玟 1杨淑珺 1李艳如 1王倩 1张翠莲1
作者信息
- 1. 郑州大学人民医院 河南大学人民医院 河南省人民医院生殖医学中心,郑州 450003
- 折叠
摘要
胚胎植入是妊娠过程中的重要限速步骤,是一个动态发育的过程,包括胚胎和子宫内膜细胞间的一系列细胞间通信及相互作用.外泌体是细胞外囊泡的一种亚型,广泛存在于细胞及体液中,可作为新的细胞间通信介质在体内发挥作用.研究表明,外泌体可参与调节胚胎发育、子宫内膜容受性、胚胎黏附、免疫耐受和血管生成等多个过程,在复杂的胚胎植入过程中发挥着重要作用.本文将对外泌体在胚胎植入中的作用进行综述,为深入探究人类胚胎植入失败原因提供新的思路.
Abstract
Embryo implantation,as an important speed limiting step in pregnancy,is a dynamic developmental process that involves a series of intercellular communication and interactions between the embryo and endometrial cells.Exosomes are a subtype of extracellular vesicles that are widely present in cells and bodily fluids and can serve as new intercellular communication mediators in the body.Research has shown that exosomes can participate in regulating embryonic development,endometrial receptivity,embryo adhesion,immune tolerance,and angiogenesis,playing an important role in regulating complex embryo implantation processes.This article will review the role of exosomes in embryo implantation,in order to provide new insights into the failure of embryo implantation in human reproduction.
关键词
外泌体/胚胎植入/细胞间通信Key words
Exosomes/Embryo implantation/Cell communication引用本文复制引用
基金项目
国家自然科学基金(U2004130)
河南省医学科技攻关计划联合共建项目(LHGJ20220045)
出版年
2024
NETL
NSTL
万方数据