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抑郁症影响生育力的研究进展

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抑郁症在我国发病率较高,但因精神卫生资源缺乏及民众认识较为落后,抑郁症患者得不到及时的识别和充分的治疗,为家庭和社会带来了沉重的负担.抑郁症可影响机体多系统功能,与多种疾病的发生密切相关.目前的证据提示,抑郁会对生育力造成损害,其表现涵盖性功能障碍、卵母细胞与精子的发育异常以及胚胎发育和植入受损等情况.本文主要总结了抑郁症影响生育力的临床研究及基础研究,以期揭示抑郁对于生育力的影响和机制.
Research progress on the impact of depression on fertility
The incidence of depression is high in China.However,due to the lack of mental health resources and the insufficient understanding of depression among the public,patients with depression cannot be identified in time and treated adequately,which brings heavy burdens to families and society.Depression can affect the functions of multiple systems in the body.It is closely related to the occurrence of various diseases.Current evidence indicates that depression can cause damage to fertility.Its manifestations include sexual dysfunction,abnormal development of oocytes and sperm,and impaired development and implantation of embryos.This article mainly summarizes the clinical and basic research on the impact of depression on fertility.We hope this article reveal the influence and mechanism of depression on fertility.

DepressionFertilityCortisolHypothalamic-pituitary-gonadal axis

钱璋、孙晓莉

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南通大学附属医院生殖医学中心,南通 226000

抑郁症 生育力 皮质醇 下丘脑-垂体-性腺轴

2024

中华生殖与避孕杂志
上海计划生育科学研究所

中华生殖与避孕杂志

CSTPCD北大核心
影响因子:0.989
ISSN:2096-2916
年,卷(期):2024.44(12)