人端粒酶逆转录酶、B细胞淋巴瘤-2基因在宫颈鳞癌中的表达及其临床意义
Expression and significance of hTERT and Bcl-2 in cervical carcinoma
任亚敏 1王修珍 1康苏娅 2顾冬梅 2虞杰 2顾振纶3
作者信息
- 1. 苏州大学医学部基础医学与生物科学院病理学与病理生理学系,江苏苏州215123
- 2. 苏州大学附属第一医院病理科,江苏苏州215006
- 3. 苏州大学中药研究所,江苏苏州215007
- 折叠
摘要
目的 探讨人端粒酶逆转录酶(hTERT)、B细胞淋巴瘤-2基因(Bcl-2)在官颈鳞癌中的表达及其临床意义.方法 应用免疫组织化学SABC法检测87例宫颈鳞癌和20例正常官颈组织中hTERT、Bcl-2的表达.结果 在正常宫颈组织和宫颈鳞癌中,hTERT表达的阳性率分别为20.0％和77.0％,其差异有高度统计学意义(P＜0.01)；Bcl-2的表达阳性率分别为35.0％和80.5％,差异也有高度统计学意义(P＜0.01)；且在宫颈鳞癌中hTERT的阳性表达与Bcl-2的阳性表达显著相关(P＜0.05).结论 hTERT和Bcl-2在宫颈鳞癌中表达显著升高,二者的表达密切相关,提示二者共同参与,并协同促进宫颈鳞癌的发生.
Abstract
Objective To investigate the expression and significance of human telomerase reverse transcriptase (hTERT) and B cell lymphoma-2 (Bcl-2) in cervical squamous cell carcinoma. Methods Expression of hTERT and Bcl-2 was detected by immunohistochemistry method in 87 cases of cervical carcinoma and 20 normal cervical speciments. Results In normal cervical speciments and cervical squamous cell carcinoma the positive rate of hTERT was 20% ,77.0% respectively, and the positive rate of Bcl-2 was 35% , 80.5% respectively, the difference in index between the two groups was significant (P <0.01). In cervical squamous cell carcinoma, the overexpression of hTERT was positively correlated to that of Bcl-2 (P <0.05). Conclusion The expression of hTERT and Bcl-2 showes over expression in cervical squamous cell carcinoma,they closely related with each other,both involved in the progression of cervical squamous cell carcinoma.
关键词
宫颈鳞癌/人端粒酶逆转录酶/B细胞淋巴瘤-2基因/免疫组化Key words
cervical squamous cell carcinoma/human telomerase reverse transcriptase/B cell lymphoma-2/immunohistochemistry引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据