Objective To investigate the effects of recombinant adenovirus expressing IL-24 (Ad-IL-24) combined with cisplatin(DDP) on growth and apoptosis of human non-small cell lung cancer NCI-H460 cells. Methods NCI-H460 cells in logarithmic phase were prepared. Effects of Ad-IL-24 combined with DDP on cell growth of NCI-H460 cells were detected by MTT assay. Cell cycle and apoptosis were analyzed by flow cytometry. Results Compared with any single group, the inhibition of cell growth and cell apoptosis in combined group are more effective. Furthermore, Ad-IL-24 combined with DDP significantly increased the ratio of cells in G2/M phase(p<0.05 or <0.01). Conclusion Recombinant adenovirus expressing IL-24 could enhance the sensitivity of lung cancer cells to chemotherapeutic drugs DDP.
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