Objective To investigate the therapeutic effect of osthole on renovascular hypertension-induced cardiac hypertrophy in rats and its possible mechanisms. Methods A rat model with cardiac hypertrophy was established by two kidney-one clip, and these rats were then treated with osthole 10 mg/kg and 20 mg/kg for 4 weeks. At the end of the experiment, the blood pressure, heart mass index, myocar-dial superoxide dismutase (SOD) , glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) contents, blood glucose and free fatty acids (FFA) in serum and myocardium were measured. Pathomorpho-logical changes of myocardial tissue were examined by light microscope. Results After treatment with osthole, the blood pressure, heart mass index, MDA in myocardium, and FFA in serum and myocardium were lowered, especially in the osthole 20 mg/kg group (P <0. 05 or P <0. 01) , while the blood glucose , the myocardial SOD and GSH-Px contents were obviously increased ( P <0.05 or P <0. 01). Moreover, the histological evaluation demonstrated that osthole could alleviate the degree of myocardial hypertrophy in rats. Conclusion Osthole was effective in the treatment of renovascular hypertension-induced cardiac hypertrophy in rats, and the main mechanisms might be related to its inhibition of oxidative stress and improvement of myocardial energy metabolism.
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维普
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